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KMID : 0378019850280020038
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New Medical Journal
1985 Volume.28 No. 2 p.38 ~ p.42
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Alteration in Follicular Fluid Steroid during Follicular Atresia in Hamster
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Abstract
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Preovulatory follicles from hamsters treated on proestrus for 1-3 days with phenobarbital sodium exhibited early signs of atresia after 2-3 days of ovulatory delay. A significant increase in follicular fluid progesterone was evident by day 1 of delay. Concentrations of androstenedione in follicular fluid were unaffected by ovulatory delay. Follicular fluid levels of estradiol in delayed follicles were either higher than proestrus values after 1 day of delay or lower after 2 and 3 days of delay. These results indicate that in the barbituratetreated hamster the elevated follicular fluid levels of progesterone precedes by 1-2 days the previously reported increase in steroidogenic capability of delayed follicles to produce progesterone in vitro.
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